Bringing you precision Cre/CreERT2 and floxed lines driven by GeneWeld CRISPR targeted integration.

Mission

Our mission is to provide the Zebrafish community with Cre resources that open new areas of investigation and promote novel discoveries in human health, development, and disease. With CRISPR/Cas9 precision targeted integration, we can generate Cre knock-ins and floxed alleles in any gene of interest, unlocking previously inaccessible cell lineages and cell type specific gene studies to broaden the scope and impact of Zebrafish research.

Funding

The Zebrafish Community Cre/lox Resource is funded by the National Institutes of Health Office of Research Infrastructure Programs.

NIH R24 OD020166 and NIH R24 OD036201

Cre Drivers

Cre and tamoxifen regulated-CreERT2 knockins for spatial and temporal analysis of proneural, mesoderm, endoderm, vascular, blood and hematopoietic stem cell lineages.

UFlip Floxed Conditional Alleles

Floxed conditional alleles in genes that regulate the epigenome and mitochondrial function, rapidly emerging areas crucial to development, disease, and regeneration. Floxed alleles allow simultaneous gene inactivation and mRFP labeling of mutant cells.